In response to 'Volume loss and altered neuronal composition in the brainstem reticular zone may not cause sudden unexpected death in epilepsy'

Abstract

We are grateful to Dr Finsterer and colleagues for the important points raised on our study which also highlight more general issues in conducting neuropathological research in SUDEP. The SUDEP cases were mainly community deaths in domestic settings, with post-mortem investigations falling under the jurisdiction of the Coroner and local pathology services. In the UK, the Royal college of Pathologists has provided guidance for the methodological approaches to these post-mortem examinations since 2006, recommending referral of brain and heart for examination to specialist centres or mandatory minimum histology of organs.