Journal article

Peripheral neutrophil phenotypes during management of periodontitis

Nidhi Medara, Jason C Lenzo, Katrina A Walsh, Eric C Reynolds, Neil M O'Brien-Simpson, Ivan B Darby

JOURNAL OF PERIODONTAL RESEARCH | WILEY | Published : 2020

Abstract

BACKGROUND AND OBJECTIVES: Neutrophils are emerging as a key player in periodontal pathogenesis. The surface expression of cellular markers enables functional phenotyping of neutrophils which have distinct roles in disease states. This study aimed to evaluate the effect of periodontal management on neutrophil phenotypes in peripheral blood in periodontitis patients over one year. MATERIALS AND METHODS: Peripheral blood and the periodontal parameters, mean probing depth and percentage of sites with bleeding on probing (%BOP), were collected from 40 healthy controls and 54 periodontitis patients at baseline and 3-, 6- and 12- months post-treatment. Flow cytometry was used to identify CD11b+ , ..

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