Journal article

Tandem Stenosis to Induce Atherosclerotic Plaque Instability in the Mouse

Yung Chih Chen, Jennifer Rivera, Karlheinz Peter, V Andres (ed.), B Dorado (ed.)

METHODS IN MOUSE ATHEROSCLEROSIS | HUMANA PRESS INC | Published : 2015

Abstract

Despite the number of animal models of atherosclerosis, a major limitation in research on mechanisms of plaque rupture is the lack of appropriate atherosclerotic mouse models where lesions develop and progress to a vulnerable and thus rupture-prone phenotype that is typically observed in humans. Most animal models of atherosclerosis typically represent a few but not the full combination of the characteristics seen in human unstable/ruptured plaques. Such characteristics most importantly include a thin and ruptured fibrous cap, plaque inflammation, neovascularization within the plaque (vasa vasorum), plaque hemorrhage, and intravascular (often occlusive) thrombus formation. Ideally, an animal..

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