Journal article
In Vivo Detection of Activated Platelets Allows Characterizing Rupture of Atherosclerotic Plaques with Molecular Magnetic Resonance Imaging in Mice
D von Elverfeldt, C von zur Muhlen, K Wiens, I Neudorfer, A Zirlik, M Meissner, P Tilly, AL Charles, C Bode, K Peter, JE Fabre
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
Background: Early and non-invasive detection of platelets on micro atherothrombosis provides a means to identify unstable plaque and thereby allowing prophylactic treatment towards prevention of stroke or myocardial infarction. Molecular magnetic resonance imaging (mMRI) of activated platelets as early markers of plaque rupture using targeted contrast agents is a promising strategy. In this study, we aim to specifically image activated platelets in murine atherothrombosis by in vivo mMRI, using a dedicated animal model of plaque rupture. Methods: An antibody targeting ligand-induced binding sites (LIBS) on the glycoprotein IIb/IIIa-receptor of activated platelets was conjugated to microparti..
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Awarded by German Research Foundation, DFG-grant
Funding Acknowledgements
This work was supported by grants from the German Research Foundation, DFG-grant No. MU2727/3-1 to Drs. von Elverfeldt and von zur Muhlen. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.