Journal article

Celastrol, a Triterpene Extracted From Tripterygium wilfordii Hook F, Inhibits Platelet Activation

Houyuan Hu, Andreas Straub, Zhuo Tian, Nicole Bassler, Jun Cheng, Karlheinz Peter

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2009

Abstract

Celastrol is an active ingredient of the traditional Chinese medicinal plant, Tripterygium wilfordii Hook F, which is known especially for its anti-inflammatory effects. However, on the cellular and molecular levels, celastrol's mechanism of action is only poorly understood. Because platelets contribute to inflammatory events, this study investigates the effects of celastrol on platelet function using flow cytometry, aggregometry, and adhesion assays. In in vitro experiments with human platelets, celastrol inhibits adenosine-5-diphosphate (ADP)-induced expression of the platelet activation marker P-selectin and glycoprotein IIb/IIIa activation with 50% inhibition values of 1.62 and 1.86 micr..

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