Journal article
Implementation of proteomic biomarkers: Making it work
H Mischak, JPA Ioannidis, A Argiles, TK Attwood, E Bongcam-Rudloff, M Broenstrup, A Charonis, GP Chrousos, C Delles, A Dominiczak, T Dylag, J Ehrich, J Egido, P Findeisen, J Jankowski, RW Johnson, BA Julien, T Lankisch, HY Leung, D Maahs Show all
European Journal of Clinical Investigation | WILEY | Published : 2012
Abstract
While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implementation. Some of the problems lie in suboptimal biomarker discovery and validation, especially lack of validated platforms with well-described performance characteristics to support biomarker qualification. These issues have been acknowledged and are being addressed, raising the hope that valid biomarkers may start accumulating in the foreseeable future. However, successful biomar..
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Awarded by European Commission
Funding Acknowledgements
This study is supported in part by the EuroKUP COST Action (BM0702) and the and by the European Community's 7th Framework Programme, grant agreement number HEALTH-F2-2009-241544 (SysKID). We would like to thank Aurelien Despierris for designing the cartoon (Fig. 1). Several of the authors are employed in part or fully by industry, and/or receive funding from industry, as also evident from their affiliations, but the article does not show partiality towards specific industry products or otherwise.