Journal article

Statistical methods used in the estimation of age-specific paediatric reference intervals for laboratory blood tests: A systematic review

Monsurul Hoq, Louise Canterford, Susan Matthews, Gulshan Khanom, Vera Ignjatovic, Paul Monagle, Susan Donath, John Carlin

Clinical Biochemistry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020


INTRODUCTION: There is an emerging realisation that paediatric reference intervals (RIs) estimated using discrete age-groups may be misleading, especially close to age cut-off values. This limitation has been addressed by estimating RIs that vary continuously with age. This systematic review examines the range of statistical methods used over the past 25 years for estimation of age-specific RIs, and identifies trends in usage and reporting. METHODS: Literature searches were conducted using predefined search criteria for original publications between 1993 and 2018 on the MEDLINE and Embase databases. Data related to sample size, treatment of age (as categorical or continuous), and statistical..

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Awarded by Royal Children's Hospital Foundation

Awarded by National Health Medical Research Council (NHMRC)

Funding Acknowledgements

Mr. Monsurul Hoq was supported by The Royal Children's Hospital Foundation [grant number 233, 2014] and a National Health Medical Research Council (NHMRC) Post Graduate Scholarship [grant number APP1168363, 2019].