Journal article

Managing radioiodine refractory thyroid cancer: the role of dosimetry and redifferentiation on subsequent I-131 therapy

Maaike Dotinga, Dennis Vriens, Floris van Velden, Linda Heijmen, James Nagarajah, Rodney Hicks, Ellen Kapiteijn, Lioe-Fee de Geus-Oei

Quarterly Journal of Nuclear Medicine and Molecular Imaging | EDIZIONI MINERVA MEDICA | Published : 2020

Abstract

Poor responses to iodine-131 (I-131) therapy can relate to either low iodine uptake and retention in thyroid cancer cells or to increased radioresistance. Both mechanisms are currently termed radioactive iodine (RAI)-refractory (RAI-R) thyroid cancer but the first reflects unsuitability for I-131 therapy that can be evaluated in advance of treatment, whereas the other can only be identified post hoc. Management of both represents a considerable challenge in clinical practice as failure of I-131 therapy, the most effective treatment of metastatic thyroid cancer, is associated with a poor overall prognosis. The development of targeted therapies has shown substantial promise in the treatment of..

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