Journal article

Marked mitochondrial genetic variation in individuals and populations of the carcinogenic liver fluke Clonorchis sinensis

Liina Kinkar, Pasi K Korhonen, Daxi Wang, Xing-Quan Zhu, Galina N Chelomina, Tao Wang, Ross S Hall, Anson Koehler, Ivon Harliwong, Bicheng Yang, J Lynn Fink, Neil D Young, Robin B Gasser

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2020

Abstract

Clonorchiasis is a neglected tropical disease caused by the Chinese liver fluke, Clonorchis sinensis, and is often associated with a malignant form of bile duct cancer (cholangiocarcinoma). Although some aspects of the epidemiology of clonorchiasis are understood, little is known about the genetics of C. sinensis populations. Here, we conducted a comprehensive genetic exploration of C. sinensis from endemic geographic regions using complete mitochondrial protein gene sets. Genomic DNA samples from C. sinensis individuals (n = 183) collected from cats and dogs in China (provinces of Guangdong, Guangxi, Hunan, Heilongjiang and Jilin) as well as from rats infected with metacercariae from cyprin..

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Grants

Awarded by Agricultural Science and Technology Innovation Program (ASTIP)


Funding Acknowledgements

Research funding from the Australian Research Council (ARC) is gratefully acknowledged (RBG, NDY and PKK). XQZ is supported by the Agricultural Science and Technology Innovation Program (ASTIP) (grant no. CAAS-ASTIP-2016-LVRI-03). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.