Journal article

Risk of Leukemia in Children With Peripheral Facial Palsy

Franz E Babl, Amit Kochar, Michael Osborn, Meredith L Borland, Adam West, Amanda Williams, Stuart R Dalziel



Most children with peripheral facial palsy will not have a cause identified. Although leukemia can cause facial nerve palsy, the magnitude of the risk is unknown and recommendations for investigations are variable. We are currently conducting a randomized, placebo-controlled trial of prednisolone for the treatment of Bell's palsy in children within the Paediatric Research in Emergency Departments International Collaborative emergency research network. In the course of the assessment for eligibility of the trial, from 644 acute-onset facial palsy presentations we identified 5 children with previously undiagnosed leukemia. We estimate the rate of leukemia in children with acute-onset facial pa..

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Awarded by National Health and Medical Research Council (NHMRC), Canberra, Australia

Funding Acknowledgements

By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see authors have stated that no such relationships exist. Funded by grants from the National Health and Medical Research Council (NHMRC) (grant GNT1078069, Centre of Research Excellence grant GNT1058560), Canberra, Australia; the Murdoch Children's Research Institute, Melbourne, Australia; the Princess Margret Hospital Foundation, Perth, Australia; and the Victorian Government's Operational Infrastructure Support program. Dr. Babl was partly funded by an NHMRC Practitioner Fellowship, a Melbourne Campus Clinician Scientist Fellowship, and a grant from the Royal Children's Hospital Foundation, Melbourne, Victoria, Australia. Dr. Dalziel was funded by Cure Kids New Zealand. Aspen Australia (St Leonards NSW 2065, Australia) donated the study drug (prednisolone and taste-matched placebo).