Conference Proceedings

Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis

Daniel J Hauke, Andre Schmidt, Erich Studerus, Christina Andreou, Anita Riecher-Roessler, Joaquim Radua, Joseph Kambeitz, Anne Ruef, Dominic B Dwyer, Lana Kambeitz-Ilankovic, Theresa Lichtenstein, Rachele Sanfelici, Nora Penzel, Shalaila S Haas, Linda A Antonucci, Paris Alexandros Lalousis, Katharine Chisholm, Frauke Schultze-Lutter, Stephan Ruhrmann, Jarmo Hietala Show all



Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models’ ability to predict functional outcomes in CHR and their transd..

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