Journal article

Cocaine and amphetamine regulated transcript (CART) signalling in the central nucleus of the amygdala modulates stress-induced alcohol seeking

Leigh C Walker, Lexi J Hand, Bethany Letherby, Kate L Huckstep, Erin J Campbell, Andrew J Lawrence

NEUROPSYCHOPHARMACOLOGY | SPRINGERNATURE | Published : 2020

Abstract

The central nucleus of the amygdala (CeA) is a key hub of the neural circuitry regulating alcohol and stress interactions. However, the exact neuronal populations that govern this interaction are not well defined. Here we examined the role of the neuropeptide cocaine and amphetamine regulated transcript (CART) within the CeA in stress-induced alcohol seeking. We found that CART-containing neurons are predominantly expressed in the capsular/lateral division of the CeA and are a subpopulation of protein kinase Cδ (PKCδ) cells, distinct from corticotrophin releasing factor (CRF)-expressing cells. Both stress (yohimbine) and stress-induced alcohol seeking activated CART cells within the CeA, whi..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

These studies were supported by a National Health and Medical Research Council (NHMRC) of Australia project grant (1079893) awarded to EJC and AJL, a Principal Research Fellowship (1116930) awarded to AJL, and a University of Melbourne ECR grant awarded to LCW. We acknowledge the Victorian State Government Operational Infrastructure Program. The authors have no financial interests relating to the work described and declare no conflict of interest.