Journal article

Associations of Height With the Risks of Colorectal and Endometrial Cancer in Persons With Lynch Syndrome

Jesca GM Brouwer, Polly A Newcomb, Tanya M Bisseling, Jane C Figueiredo, John L Hopper, Mark A Jenkins, Jan J Koornstra, Noralane M Lindor, Hans FA Vasen, Aung K Win, Ellen Kampman, Franzel JB van Duijnhoven

AMERICAN JOURNAL OF EPIDEMIOLOGY | OXFORD UNIV PRESS INC | Published : 2021

Abstract

Persons with Lynch syndrome (LS - carrying a pathogenic mutation in a DNA mismatch repair gene) have an increased colorectal cancer (CRC) and endometrial cancer (EC) risk. A high reported variability in cancer risk suggests the existence of factors that modify cancer risk for LS. We aimed to investigate the association between height and CRC and EC for persons with LS using two large studies. Information of 1,213 men and 1,636 women with LS from the Colon Cancer Family Registry (1998-2007) and the GEOLynch cohort study (2006-2017) was harmonized. We used weighted Cox proportional hazard regression models with age on the time-axis to estimate adjusted hazard ratios (HR) and 95% confidence int..

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Grants

Awarded by Wereld Kanker Onderzoek Fonds Netherlands as part of the World Cancer Research Fund International grant program


Awarded by National Cancer Institute, US National Institutes of Health


Funding Acknowledgements

The GEOLynch Cohort Study is supported by the Wereld Kanker Onderzoek Fonds Netherlands as part of the World Cancer Research Fund International grant program (grant 2014/1184). The Colon Cancer Family Registry is supported in part by funding from the National Cancer Institute, US National Institutes of Health (award U01CA167551). Support for case ascertainment was provided in part by the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) Program and 5 US state cancer registries (Arizona, Colorado, Minnesota, North Carolina, and New Hampshire) and by the Victorian Cancer Registry (Melbourne, Victoria, Australia) and the Ontario Cancer Registry (Toronto, Ontario, Canada).