Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial
Paul A Agius, Julia C Cutts, Win Han Oo, Aung Thi, Katherine O'Flaherty, Kyaw Zayar Aung, Htin Kyaw Thu, Poe Poe Aung, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, Zahra Razook, Alyssa E Barry, Win Htike, Angela Devine, Julie A Simpson, Brendan S Crabb, James G Beeson, Naanki Pasricha Show all
PLoS Medicine | PUBLIC LIBRARY SCIENCE | Published : 2020
BACKGROUND: The World Health Organization has yet to endorse deployment of topical repellents for malaria prevention as part of public health campaigns. We aimed to quantify the effectiveness of repellent distributed by the village health volunteer (VHV) network in the Greater Mekong Subregion (GMS) in reducing malaria in order to advance regional malaria elimination. METHODS AND FINDINGS: Between April 2015 and June 2016, a 15-month stepped-wedge cluster randomised trial was conducted in 116 villages in Myanmar (stepped monthly in blocks) to test the effectiveness of 12% N,N-diethylbenzamide w/w cream distributed by VHVs, on Plasmodium spp. infection. The median age of participants was 18 y..View full abstract
Awarded by Three Millennium Development Goal (3MDG) fund
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council (Australian Centre for Research Excellence in Malaria Elimination (ACREME))
The implementation of malaria services in Myanmar was supported by Three Millennium Development Goal (3MDG) fund (BI-MARC-3MDG-C2-14-00089847). Further funding was received from the Australian Research Council (Future Fellowship to FJIF, FT130101122) and the National Health and Medical Research Council (Australian Centre for Research Excellence in Malaria Elimination (ACREME) to FJIF, JAS, JGB (1134989); Career Development Fellowship to FJIF (1166753); Senior Research Fellowship to JGB (1077636) and JAS (1104975); and its Independent Research Institute Infrastructure Support Scheme). The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.