Journal article

Sex is associated with the persistence of non-optimal vaginal microbiota following treatment for bacterial vaginosis: a prospective cohort study

LK Ratten, EL Plummer, GL Murray, J Danielewski, CK Fairley, SM Garland, JS Hocking, G Tachedjian, EPF Chow, CS Bradshaw, LA Vodstrcil

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | WILEY | Published : 2020

Abstract

OBJECTIVE: Determine the associations between factors and sexual practices and the composition of the vaginal microbiome (VM) of women treated for bacterial vaginosis (BV). DESIGN: Prospective cohort study. SETTING: The Melbourne Sexual Health Centre, Melbourne, Australia. POPULATION: Seventy-five reproductive-age women diagnosed with clinical BV, treated with first-line antibiotics and followed for up to 6 months. METHODS: Women self-collected vaginal swabs and completed questionnaires at enrolment, the day following antibiotics and monthly for up to 6months until BV recurrence or no BV recurrence (n = 430 specimens). Bacterial composition was determined using 16S rRNA gene amplicon sequenc..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC) Program Grant


Awarded by NHMRC Leadership Investigator Grants


Awarded by NHMRC Senior Research Fellowship


Awarded by NHMRC Emerging Leadership Investigator Grant


Funding Acknowledgements

This original trial was supported by a grant from Monash University (Near Miss) awarded to CSB and an Early Career Researcher grant from The University of Melbourne (Australia) to LAV. This work was also supported by an Australian National Health and Medical Research Council (NHMRC) Program Grant (1071269) awarded to CKF and SMG. CSB and CKF are supported by NHMRC Leadership Investigator Grants (1173361, 1172900, respectively), GT by an NHMRC Senior Research Fellowship (1117748) and EPFC by an NHMRC Emerging Leadership Investigator Grant (1172873).