Journal article
Intracranial efficacy and survival with tucatinib plus trastuzumab and capecitabine for previously treated HER2-positive breast cancer with brain metastases in the HER2CLIMB trial
NU Lin, V Borges, C Anders, RK Murthy, E Paplomata, E Hamilton, S Hurvitz, S Loi, A Okines, V Abramson, PL Bedard, M Oliveira, V Mueller, A Zelnak, MP DiGiovanna, T Bachelot, A Jo Chien, R O’Regan, A Wardley, A Conlin Show all
Journal of Clinical Oncology | AMER SOC CLINICAL ONCOLOGY | Published : 2020
DOI: 10.1200/JCO.20.00775
Open access
Abstract
PURPOSE In the HER2CLIMB study, patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer with brain metastases (BMs) showed statistically significant improvement in progression-free survival (PFS) with tucatinib. We describe exploratory analyses of intracranial efficacy and survival in participants with BMs. PATIENTS AND METHODS Patients were randomly assigned 2:1 to tucatinib or placebo, in combination with trastuzumab and capecitabine. All patients underwent baseline brain magnetic resonance imaging; those with BMs were classified as active or stable. Efficacy analyses were performed by applying RECIST 1.1 criteria to CNS target lesions by investigator assessmen..
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Awarded by National Cancer Institute
Funding Acknowledgements
Supported by Seattle Genetics (Bothell, WA), the manufacturer of tucatinib, which also funded writing assistance in accordance with Good Publications Practice guidelines.