Journal article

The Intestinal Virome and Immunity

Jessica A Neil, Ken Cadwell

The Journal of Immunology | AMER ASSOC IMMUNOLOGISTS | Published : 2018

Abstract

The composition of the human microbiome is considered a major source of interindividual variation in immunity and, by extension, susceptibility to diseases. Intestinal bacteria have been the major focus of research. However, diverse communities of viruses that infect microbes and the animal host cohabitate the gastrointestinal tract and collectively constitute the gut virome. Although viruses are typically investigated as pathogens, recent studies highlight a relationship between the host and animal viruses in the gut that is more akin to host-microbiome interactions and includes both beneficial and detrimental outcomes for the host. These viruses are likely sources of immune variation, both..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Funding Acknowledgements

This work was supported by National Institutes of Health Grants HL123340, DK093668, DK103788, and AI121244, a Faculty Scholar grant from the Howard Hughes Medical Institute, the Stony Wold-Herbert Fund, the Merieux Institute, the Rainin Foundation, a Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases award (to K.C.), a Sir Keith Murdoch Fellowship, and a Vilcek Fellowship (to J.A.N.).