In Vitro and In Vivo Toxicity and Biodistribution of Paclitaxel-Loaded Cubosomes as a Drug Delivery Nanocarrier: A Case Study Using an A431 Skin Cancer Xenograft Model
Jiali Zhai, Fiona H Tan, Rodney B Luwor, T Srinivasa Reddy, Nuzhat Ahmed, Calum J Drummond, Nhiem Tran
ACS APPLIED BIO MATERIALS | AMER CHEMICAL SOC | Published : 2020
Cubosomes with an internal three-dimensional (3D) periodic and porous particulate nanostructure have emerged as a promising drug delivery system for hydrophobic small molecules as well as large biomolecules over the past several decades. Limited understanding of their safety profiles and biodistribution, however, hinders clinical translation. This study used monoolein-based cubosomes stabilized by Pluronic F127 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)] polymers to encapsulate paclitaxel (PTX) as a model drug and investigated the in vitro cytotoxicity, in vivo acute response, and whole body biodistribution of the developed nanoparticles. Comparison..View full abstract
The authors thank Dr. Julian Ratcliffe for conducting the cryoTEM examination. The authors acknowledge the Capability Development Fund Scheme of RMIT University, the Maxwell Eagle Endowment Award and the CASS Foundation Science/Medicine Grant for financial support. N.T. is a recipient of an RMIT Vice-Chancellor's Research Fellowship.