Journal article

Longitudinal Stroke Recovery Associated With Dysregulation of Complement System-A Proteomics Pathway Analysis

Vinh A Nguyen, Nina Riddell, Sheila G Crewther, Pierre Faou, Harinda Rajapaksha, David W Howells, Graeme J Hankey, Tissa Wijeratne, Henry Ma, Stephen Davis, Geoffrey A Donnan, Leeanne M Carey

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Currently the longitudinal proteomic profile of post-ischemic stroke recovery is relatively unknown with few well-accepted biomarkers or understanding of the biological systems that underpin recovery. We aimed to characterize plasma derived biological pathways associated with recovery during the first year post event using a discovery proteomics workflow coupled with a topological pathway systems biology approach. Blood samples (n = 180, ethylenediaminetetraacetic acid plasma) were collected from a subgroup of 60 first episode stroke survivors from the Australian START study at 3 timepoints: 3-7 days (T1), 3-months (T2) and 12-months (T3) post-stroke. Samples were analyzed by liquid chromato..

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Grants

Awarded by James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation Collaborative Award


Awarded by NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury


Awarded by NHMRC program grant Saving brain and changing practice in stroke


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

We acknowledge financial support for conduct of the START_EXTEND and START_PrePARE studies from the Commonwealth Scientific and Industrial Research Organization (CSIRO) of Australia, Flagship Collaboration Fund through the Preventative Health Flagship and support for analysis, write up and researchers from the James S. McDonnell Foundation 21st Century Science Initiative in Cognitive Rehabilitation Collaborative Award (# 220020413); NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Injury (#1077898); NHMRC program grant Saving brain and changing practice in stroke (#1113352); Victorian Government's Operational Infrastructure Support Program; an Australian Research Council Future Fellowship awarded to LC [#FT0992299]; and a La Trobe University Post Graduate Scholarship supported by the Understanding Diseases research focus group awarded to VN. The funding sources had no role in the conduct of this study or the writing of this report.