The impact of size and charge on the pulmonary phatmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats
Shadabul Haque, Colin W Pouton, Michelle P McIntosh, David B Ascher, David W Keizer, Michael R Whittaker, Lisa M Kaminskas
Nanomedicine Nanotechnology Biology and Medicine | ELSEVIER | Published : 2020
Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inhaled delivery. Despite their advantages as inhalable nanomedicine scaffolds, we still lack a complete understanding of the kinetics and major pathways by which these materials are cleared from the lungs. This information is important to evaluate their safety over prolonged use and enable successful clinical translation. This study aimed to determine how the size and charge of 3H-labeled PLGA nanoparticles affect the kinetics and mechanisms by which they are cleared from the lungs and their safety in the lungs. The results showed that lung clearance kinetics and ret..View full abstract
SH was supported by a Victoria India doctoral scholarship. LMK was supported by an NHMRC Career Development fellowship. This work was partlyf unded by ARC Discovery and NHMRC Project grant schemes.