Journal article

Innate and adaptive immunity toward influenza B viruses

Luca Hensen, Katherine Kedzierska, Marios Koutsakos

Future Microbiology | FUTURE MEDICINE LTD | Published : 2020

Abstract

Despite annual vaccination, influenza B viruses (IBV) cause significant disease with substantial health and socio-economic impacts. Novel vaccination strategies inducing broadly protective and long-lasting immunity across IBV lineages are needed. However, as immune responses toward IBV are largely understudied, host-virus interactions and protective immune mechanisms need to be defined to rationally design such vaccines. Here, we summarize recent advances in our understanding of immunological mechanisms underpinning protection from IBV. We discuss how innate antiviral host factors inhibit IBV replication and the ways by which IBV escapes such restriction. We review the specificity of broadly..

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Grants

Awarded by NHMRC Senior Research Fellowship Level B


Funding Acknowledgements

K Kedzierska is supported by an NHMRC Senior Research Fellowship Level B (#1102792). L Hensen is supported by the Melbourne International Research Scholarship (MIRS) and the Melbourne International Fee Remission Scholarship (MIFRS) from The University of Melbourne. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.