Journal article

Differential expression of soluble receptor for advanced glycation end-products (sRAGE) in mice susceptible or resistant to chronic colitis

Michael Bramhall, Kevin Rich, Ajanta Chakraborty, Larisa Logunova, Namshik Han, James Wilson, Catherine Booth, John Mclaughlin, Andy Brass, Sheena Cruickshank

Published : 2019


Aims Identifying the factors that contribute to chronicity in inflamed colitic tissue is not trivial. However, in mouse models of colitis, we can investigate at preclinical timepoints. We sought to validate murine Trichuris muris infection as a model for identification of factors that promote development of chronic colitis. Methods We compared preclinical changes in mice with a resolving immune response to T. muris (resistant) versus mice that fail to expel the worms and develop chronic colitis (susceptible). Findings were then validated in healthy controls and patients with suspected or confirmed IBD. Results The Receptor for Advanced Glycation End Products ( Rage ) was highly dysregulated ..

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