Mastering gut permeability: New roles for old friends
Michael Bramhall, Colby Zaph
EUROPEAN JOURNAL OF IMMUNOLOGY | WILEY | Published : 2017
Mast cells are innate immune cells that respond rapidly to infection in barrier tissues such as the skin and intestinal mucosa. Expulsion of parasitic worms in the gut involves a robust type 2 host response, and an acute mastocytosis is often generated at the site of infection. However, the role of mast cells in resistance to worm infections appears to be parasite specific. Mast cells are also involved in tissue repair, but the long-term contribution of mast cell activation after worm expulsion has not been definitively studied. In this issue of European Journal of Immunology, Sorobetea et al. [Eur. J. Immunol. 2017. 47: 257-268] demonstrate that activated mast cells persist in the large int..View full abstract
Awarded by National Health and Medical Research Council
This work is supported by the National Health and Medical Research Council (project grants 1104433 and 1104466 to C.Z.) and veski (veski innovation fellowship to C.Z.).