Quality of Methods Reporting in Animal Models of Colitis
Michael Bramhall, Oscar Florez-Vargas, Robert Stevens, Andy Brass, Sheena Cruickshank
Inflammatory Bowel Diseases | OXFORD UNIV PRESS INC | Published : 2015
BACKGROUND: Current understanding of the onset of inflammatory bowel diseases relies heavily on data derived from animal models of colitis. However, the omission of information concerning the method used makes the interpretation of studies difficult or impossible. We assessed the current quality of methods reporting in 4 animal models of colitis that are used to inform clinical research into inflammatory bowel disease: dextran sulfate sodium, interleukin-10, CD45RB T cell transfer, and 2,4,6-trinitrobenzene sulfonic acid (TNBS). METHODS: We performed a systematic review based on PRISMA guidelines, using a PubMed search (2000-2014) to obtain publications that used a microarray to describe gen..View full abstract
Awarded by Engineering and Physical Sciences Research Council
Supported by a co-funding scholarship from EPSRC and Epistem Ltd awarded to M. Bramhall and a "Francisco Jose de Caldas" scholarship from Colciencias to O. Florez-Vargas.