A role for the pattern recognition receptor Nod2 in promoting recruitment of CD103( ) dendritic cells to the colon in response to Trichuris muris infection
R Bowcutt, M Bramhall, L Logunova, J Wilson, C Booth, SR Carding, R Grencis, S Cruickshank
Mucosal Immunology | NATURE PUBLISHING GROUP | Published : 2014
The ability of the colon to generate an immune response to pathogens, such as the model pathogen Trichuris muris, is a fundamental and critical defense mechanism. Resistance to T. muris infection is associated with the rapid recruitment of dendritic cells (DCs) to the colonic epithelium via epithelial chemokine production. However, the epithelial-pathogen interactions that drive chemokine production are not known. We addressed the role of the cytosolic pattern recognition receptor Nod2. In response to infection, there was a rapid influx of CD103(+)CD11c(+) DCs into the colonic epithelium in wild-type (WT) mice, whereas this was absent in Nod2(-/-) animals. In vitro chemotaxis assays and in v..View full abstract
Awarded by Wellcome Trust
Awarded by Biotechnology and Biological Sciences Research Council
Awarded by Engineering and Physical Sciences Research Council
This study was supported by the Biotechnology and Biological Sciences Research Council, UK (to S. C.) and Epistem. R. G. was supported by the Wellcome Trust grant number 083620/Z/07/Z. A special thanks to Dr Kaye Williams and Epistem for their help with the generation of bone marrow chimeras.