Journal article

Characterization of Sodium Channel Mutations in the Dengue Vector MosquitoesAedesaegyptiandAedesalbopictuswithin the Context of OngoingWolbachiaReleases in Kuala Lumpur, Malaysia

Noor Afizah Ahmad, Nancy M Endersby-Harshman, Nur Ruqqayah Mohd Mazni, Nur Zatil Aqmar Mohd Zabari, Siti Nor Syazwani Amran, Muhammad Kamarul Ridhuan Ghazali, Mohd Arif Abdul Karim, Yoon Ling Cheong, Steven P Sinkins, Nazni Wasi Ahmad, Ary A Hoffmann

INSECTS | MDPI | Published : 2020


Specific sodium channel gene mutations confer target site resistance to pyrethroid insecticides in mosquitoes and other insects. In Aedes mosquito species, multiple mutations that contribute to resistance vary in their importance around the world. Here, we characterize voltage sensitive sodium channel (Vssc) mutations in populations of Aedesaegypti from Kuala Lumpur, Malaysia, and look at their persistence in populations affected by ongoing Wolbachia releases (a dengue control measure). We also describe a Vssc mutation in Aedesalbopictus (F1534L) found for the first time in Malaysia. We show that there are three predominant Vssc haplotypes in Aedesaegypti in this region, which all persist wi..

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Awarded by Wellcome Trust

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This research was funded by the Wellcome Trust Award 108508, the National Health and Medical Research Council (Program Grants 1037003, 1132412) and the Ministry of Health Malaysia.