Physical Functioning, Mental Health, and Quality of Life in Different Congenital Heart Defects: Comparative Analysis in 3538 Patients From 15 Countries
Philip Moons, Koen Luyckx, Corina Thomet, Werner Budts, Junko Enomoto, Maayke A Sluman, Chun-Wei Lu, Jamie L Jackson, Paul Khairy, Stephen C Cook, Shanthi Chidambarathanu, Luis Alday, Katrine Eriksen, Mikael Dellborg, Malin Berghammer, Bengt Johansson, Andrew S Mackie, Samuel Menahem, Maryanne Caruana, Gruschen Veldtman Show all
CANADIAN JOURNAL OF CARDIOLOGY | ELSEVIER SCIENCE INC | Published : 2021
BACKGROUND: We compared physical functioning, mental health, and quality of life (QoL) of patients with different subtypes of congenital heart disease (CHD) in a large international sample and investigated the role of functional class in explaining the variance in outcomes across heart defects. METHODS: In the cross-sectional Assessment of Patterns of Patient-Reported Outcome in Adults with Congenital Heart Disease-International Study (APPROACH-IS), we enrolled 4028 adult patients with CHD from 15 countries. Diagnostic groups with at least 50 patients were included in these analyses, yielding a sample of 3538 patients (median age: 32 years; 52% women). Physical functioning, mental health, an..View full abstract
Awarded by Research Fund-KU Leuven, Leuven, Belgium
Awarded by Swedish Heart-Lung Foundation, Sweden
Awarded by Cardiac Children's Foundation, Taiwan
This work was supported by the Research Fund-KU Leuven, Leuven, Belgium, through grant OT/11/033 (to K.L. and P.M.); by the Swedish Heart-Lung Foundation, Sweden, through grant number 20130607 (to M.D.); by the University of Gothenburg Centre for Person-Centred Care, Gothenburg, Sweden (to M.D. and P.M.); and by the Cardiac Children's Foundation, Taiwan, through grant CCF201302 (to H.L.Y.). This work was endorsed by, and conducted in collaboration with, the International Society for Adult Congenital Heart Disease. Registration: ClinicalTrials.gov: NCT02150603.