Calcium and cyclic nucleotide signaling networks in Toxoplasma gondii

Abstract

Apicomplexan parasites of medical or veterinary interest are obligate intracellular parasites that display actin-myosin powered motility, control the secretion of adhesive proteins, and actively penetrate their host cells. Following an intracellular replicative phase, they emerge from their spent host cell by a process of active egress. The transition between these two modes of active motility, required for invasion/egress, versus a nonmotile state required for intracellular replication must be balanced to respond to environmental clues and promote efficient growth. These processes are regulated by two interrelated signaling pathways that control intracellular calcium and cyclic nucleotides...