Metabolic networks and metabolomics

Abstract

Major advances have been made in our understanding of Toxoplasma gondii metabolism, through the use of computational approaches, comprehensive metabolomic analyses, and high-throughput CRISPR/Cas9 knockout studies. Delineation of the metabolic potential of different parasite developmental stages is driving current efforts to identify new drug targets, determine the mode of action of antitoxoplasmosis drugs, discover new biomarkers, and to understand the effects that the parasite has on its host. We review here recent advances in developing an in silico model of T. gondii metabolism, as well as the current knowledge of T. gondii central carbon metabolism and its requirements for the synthesis..