Journal article

Synchronized Inflations Generate Greater Gravity-Dependent Lung Ventilation in Neonates

Georgie Dowse, Elizabeth Perkins, Jessica Thomson, Nicholas Schinckel, Prue Pereira-Fantini, David Tingay

The Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2021

Abstract

OBJECTIVE: To describe the regional distribution patterns of tidal ventilation within the lung during mechanical ventilation that is synchronous or asynchronous with an infant's own breathing effort. STUDY DESIGN: Intubated infants receiving synchronized mechanical ventilation at The Royal Children's Hospital neonatal intensive care unit were studied. During four 10-minute periods of routine care, regional distribution of tidal volume (VT; electrical impedance tomography), delivered pressure, and airway flow (Florian Respiratory Monitor) were measured for every inflation. Post hoc, each inflation was then classified as synchronous or asynchronous from video data of the ventilator screen, and..

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Grants

Awarded by National Health and Medical Research Council Clinical Career Development Fellowship


Funding Acknowledgements

Supported by the Victorian Government Operational Infrastructure Support Program (Melbourne, Australia). G.D. and N.S. received an MCRI Honours student scholarship. D.T. is supported by a National Health and Medical Research Council Clinical Career Development Fellowship (1053889). SenTec AG (Landquart, Switzerland) manufactured custom-built EIT belts for infants. All EIT hardware was purchased by Murdoch Children's Research Institute (MCRI) without any restrictions. The authors declare no conflicts of interest.