Journal article

Trends in Bone Metastasis Modeling

Roberta Laranga, Serena Duchi, Toni Ibrahim, Ania Naila Guerrieri, Davide Maria Donati, Enrico Lucarelli

Cancers | MDPI | Published : 2020

Abstract

Bone is one of the most common sites for cancer metastasis. Bone tissue is composed by different kinds of cells that coexist in a coordinated balance. Due to the complexity of bone, it is impossible to capture the intricate interactions between cells under either physiological or pathological conditions. Hence, a variety of in vivo and in vitro approaches have been developed. Various models of tumor-bone diseases are routinely used to provide valuable information on the relationship between metastatic cancer cells and the bone tissue. Ideally, when modeling the metastasis of human cancers to bone, models would replicate the intra-tumor heterogeneity, as well as the genetic and phenotypic cha..

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Grants

Awarded by Ministero della Salute Progetto Finalizzata


Funding Acknowledgements

We would like to acknowledge the projects leading to this publication: Dinamica received funding from POR FERSR 2014 2020 and the project Biobos has received funding from the Ministero della Salute Progetto Finalizzata GR-2016-02364704. This work was also funded by the Italian Health Ministry 5 - 1000 fund.