Validation of the focal cerebral arteriopathy severity score (FCASS) in a Swiss cohort: Correlation with infarct volume and outcome
Nedelina Slavova, Heather J Fullerton, Nancy K Hills, Philipe S Breiding, Mark T Mackay, Maja Steinlin
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | ELSEVIER SCI LTD | Published : 2020
BACKGROUND: Focal cerebral arteriopathy (FCA), a major cause of childhood arterial ischemic stroke (AIS), can progress and lead to increased infarct size and/or recurrent stroke. Evaluating treatment options depends on the ability to quantify reliably the degree of stenosis in FCA. AIMS: We validated the recently introduced FCA severity score (FCASS) in an independent cohort from the Swiss Neuro-Paediatric Stroke Registry (SNPSR). MATERIALS AND METHODS: We included children with FCA who had MR or CT angiography and a Pediatric Stroke Outcome Measure (PSOM) at 6-months and 2-years post-stroke. A paediatric neuroradiologist applied the FCASS and the modified pediatric Alberta Stroke Program Ea..View full abstract
The work within the Swiss Neuropaediatric Stroke Registry SNPSR has been supported by Novartis Research Foundation, Swiss Heart Foundation, Stiftung fur neuropsychiatrische Forschung, Fondazione Ettore e Valeria Rossi, Anna Mueller Grocholski Stiftung, Batzebar Kinderkliniken Bern. We thank Inselgruppe Bern for the visiting professorship of Prof. Heather Fullerton.