Is multileaf collimator tracking or gating a better intrafraction motion adaptation strategy? An analysis of the TROG 15.01 stereotactic prostate ablative radiotherapy with KIM (SPARK) trial
Emily A Hewson, Doan T Nguyen, Ricky O'Brien, Per R Poulsen, Jeremy T Booth, Peter Greer, Thomas Eade, Andrew Kneebone, George Hruby, Trevor Moodie, Amy J Hayden, Sandra L Turner, Nicholas Hardcastle, Shankar Siva, Keen Hun Tai, Jarad Martin, Paul J Keall
RADIOTHERAPY AND ONCOLOGY | ELSEVIER IRELAND LTD | Published : 2020
PURPOSE: Stereotactic Ablative Radiotherapy (SABR) has recently emerged as a favourable treatment option for prostate cancer patients. With higher doses delivered over fewer fractions, motion adaptation is a requirement for accurate delivery of SABR. This study compared the efficacy of multileaf collimator (MLC) tracking vs. gating as a real-time motion adaptation strategy for prostate SABR patients enrolled in a clinical trial. METHODS: Forty-four prostate cancer patients treated over five fractions in the TROG 15.01 SPARK trial were analysed in this study. Forty-nine fractions were treated using MLC tracking and 166 fractions were treated using beam gating and couch shifts. A time-resolved..View full abstract
Awarded by Cancer Australia
Awarded by National Health AMP; Medical Research Council of Australia
This work was supported by Cancer Australia (APP1081534), the Prostate Cancer Foundation of Australia, and the National Health & Medical Research Council of Australia (APP1112096, APP1138807).