Journal article

Frequency of kdr mutations in the voltage-sensitive sodium channel (V-SSC) gene in Aedes aegypti from Yogyakarta and implications for Wolbachia-infected mosquito trials

Juli Rochmijati Wuliandari, Ary A Hoffmann, Warsito Tantowijoyo, Nancy M Endersby-Harshman

Parasites & Vectors | BMC | Published : 2020

Abstract

BACKGROUND: In the inner city of Yogyakarta, Indonesia, insecticide resistance is expected in the main dengue vector, Aedes aegypti, because of the intensive local application of pyrethroid insecticides. However, detailed information about the nature of resistance in this species is required to assist the release of Wolbachia mosquitoes in a dengue control program, so that we can ensure that insecticide resistance in the strain of Ae. aegypti being released matches that of the background population. METHODS: High-resolution melt genotyping was used to screen for kdr mutations associated with pyrethroid resistance in the voltage-sensitive sodium channel (VSSC) gene in Ae. aegypti of some area..

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Grants

Awarded by National Health and Medical Research Council


Awarded by NHMRC Fellowship Grant


Funding Acknowledgements

The study was funded by the National Health and Medical Research Council with a Programme Grant/Award Numbers: 1037003, 1132412 and a Fellowship to AAH; NHMRC Fellowship Grant no. 1118640; FNIH Vector-based Control of Transmission: Discovery Research (VCTR) program Eliminate Dengue; JJT Foundation and the Tahija Foundation.