Journal article

Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders

Yash Patel, Nadine Parker, Jean Shin, Derek Howard, Leon French, Sophia I Thomopoulos, Elena Pozzi, Yoshinari Abe, Christoph Abe, Alan Anticevic, Martin Alda, Andre Aleman, Clara Alloza, Silvia Alonso-Lana, Stephanie H Ameis, Evdokia Anagnostou, Andrew A McIntosh, Celso Arango, Paul D Arnold, Philip Asherson Show all

JAMA PSYCHIATRY | AMER MEDICAL ASSOC | Published : 2021

Abstract

Importance: Large-scale neuroimaging studies have revealed group differences in cortical thickness across many psychiatric disorders. The underlying neurobiology behind these differences is not well understood. Objective: To determine neurobiologic correlates of group differences in cortical thickness between cases and controls in 6 disorders: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and schizophrenia. Design, Setting, and Participants: Profiles of group differences in cortical thickness between cases and controls were generated using T1-weighted magnetic reson..

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