Journal article

Substitutions at H134 and in the 430-loop region in influenza B neuraminidases can confer reduced susceptibility to multiple neuraminidase inhibitors

Peter G Mohr, Janelle Williams, Masato Tashiro, Victor A Streltsov, Jennifer L McKimm-Breschkin

Antiviral Research | ELSEVIER | Published : 2020

Abstract

With the introduction of the influenza specific neuraminidase inhibitors (NAIs) in 1999, there were concerns about the emergence and spread of resistant viruses in the community setting. Surveillance and testing of community isolates for their susceptibility to the NAIs was initially carried out by the Neuraminidase Inhibitor Susceptibility Network (NISN) and has subsequently been taken on by the global WHO influenza network laboratories. During the NISN surveillance, we identified two Yamagata lineage influenza B viruses with amino acid substitutions of H134Y (B/Auckland/2/2001) or W438R (B/Yokohama/12/2005) which had slightly elevated IC50 values for zanamivir and/or oseltamivir, but not s..

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Funding Acknowledgements

This work was partly funded through a grant from GlaxoSmithKline (UK). They had no role in interpretation of data or the preparation of the manuscript. The ACDP Facility is supported by the Australian Government Department of Agriculture and Water Resources and the National Collaborative Research Infrastructure Strategy (NCRIS).