Journal article

Methio "mine"! Cancer cells steal methionine and impair CD8 T-cell function

Patrick M Gubser, Axel Kallies

Immunology & Cell Biology | WILEY | Published : 2020

Abstract

Tumor cells steal methionine from CD8 T cells. High expression of the methionine transporters SLC7A5 and SLC43A2 allows tumor cells to outcompete CD8 T cells for methionine uptake. Lower methionine concentrations in CD8 T cells lead to reduced levels of dimethylated H3K79, an active epigenetic mark, which in turn results in reduced STAT5 expression and activity.