Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline
Rachel F Buckley, Matthew R Scott, Heidi IL Jacobs, Aaron P Schultz, Michael J Properzi, Rebecca E Amariglio, Timothy J Hohman, Danielle V Mayblyum, Zoe B Rubinstein, Lyssa Manning, Bernard J Hanseeuw, Elizabeth C Mormino, Dorene M Rentz, Keith A Johnson, Reisa A Sperling
Annals of Neurology | WILEY | Published : 2020
OBJECTIVE: The goal of this study was to examine sex differences in tau distribution across the brain of older adults, using positron emission tomography (PET), and investigate how these differences might associate with cognitive trajectories. METHODS: Participants were 343 clinically normal individuals (women, 58%; 73.8 [8.5] years) and 55 individuals with mild cognitive impairment (MCI; women, 38%; 76.9 [7.3] years) from the Harvard Aging Brain Study and the Alzheimer's Disease Neuroimaging Initiative. We examined 18 F-Flortaucipir (FTP)-positron emission tomography (PET) signal across 41 cortical and subcortical regions of interest (ROIs). Linear regression models estimated the effect of ..View full abstract
Awarded by National Institute on Aging
Awarded by NIA
The Harvard Aging Brain Study is funded by the National Institute on Aging (P01AG036694) with additional support from several philanthropic organizations. The Alzheimer's Disease Neuroimaging Initiative is funded by the NIA (U19AG024904), the NIBIB, the Canadian IHR, and several philanthropic organizations. Several co-authors' contributions were also supported by career development awards: R.F.B. is supported by a K99/R00 award from NIA; H.I.L. is supported by a Marie-Sklodowska-Curie Global Fellowship within the European Union's Horizon 2020 Research and Innovation Programme; and T.J.H. is supported by a K01 award from NIA.