Interorgan communication in development and cancer
Edel Alvarez-Ochoa, Francesca Froldi, Louise Y Cheng
WIREs Developmental Biology | WILEY | Published : 2020
Studies in model organisms have demonstrated that extensive communication occurs between distant organs both during development and in diseases such as cancer. Organs communicate with each other to coordinate growth and reach the correct size, while the fate of tumor cells depend on the outcome of their interaction with the immune system and peripheral tissues. In this review, we outline recent studies in Drosophila, which have enabled an improved understanding of the complex crosstalk between organs in the context of both organismal and tumor growth. We argue that Drosophila is a powerful model organism for studying these interactions, and these studies have the potential for improving our ..View full abstract
Awarded by National Health and Medical Research Council
E.A-O is funded by a Melbourne Research Scholarship. L.Y.C is supported by an ARC Future Fellowship, F.F is supported by the National Health and Medical Research Council, (Grant/Award Number: APP1044704) and the Peter MacCallum Cancer Foundation.