Viewpoint of a WHO Advisory Group Tasked to Consider Establishing a Closely-monitored Challenge Model of Coronavirus Disease 2019 (COVID-19) in Healthy Volunteers.
Myron M Levine, Salim Abdullah, Yaseen M Arabi, Delese Mimi Darko, Anna P Durbin, Vicente Estrada, Euzebiusz Jamrozik, Peter G Kremsner, Rosanna Lagos, Punnee Pitisuttithum, Stanley A Plotkin, Robert Sauerwein, Sheng-Li Shi, Halvor Sommerfelt, Kanta Subbarao, John J Treanor, Sudhanshu Vrati, Deborah King, Shobana Balasingam, Charlie Weller Show all
Clinical Infectious Diseases | Published : 2021
WHO convened an Advisory Group (AG) to consider the feasibility, potential value, and limitations of establishing a closely-monitored challenge model of experimental severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) in healthy adult volunteers. The AG included experts in design, establishment, and performance of challenges. This report summarizes issues that render a COVID-19 model daunting to establish (the potential of SARS-CoV-2 to cause severe/fatal illness, its high transmissibility, and lack of a "rescue treatment" to prevent progression from mild/moderate to severe clinical illness) and it proffers prudent strategies for ste..View full abstract