The Role of NK Cells and Innate Lymphoid Cells in Brain Cancer
Alexander James Sedgwick, Nazanin Ghazanfari, Patrick Constantinescu, Theo Mantamadiotis, Alexander David Barrow
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2020
The brain is considered an immune privileged site due to the high selectivity of the blood-brain barrier which restricts the passage of molecules and cells into the brain parenchyma. Recent studies have highlighted active immunosurveillance mechanisms in the brain. Here we review emerging evidence for the contribution of innate lymphoid cells (ILCs) including natural killer (NK) cells to the immunosurveillance of brain cancers focusing on glioblastoma, one of the most aggressive and most common malignant primary brain tumors diagnosed in adults. Moreover, we discuss how the local tissue microenvironment and unique cellular interactions influence ILC functions in the brain and how these inter..View full abstract
Awarded by Medical Research Future Fund (MRFF)
Awarded by MRFF
This work was funded by the Medical Research Future Fund (MRFF) project APP1162217-Role of the NKP44-PDGF-DD immunosurveillance pathway in glioblastoma. AB is funded by MRFF grant APP1162217.