Journal article

Long noncoding RNAs: Important participants and potential therapeutic targets for myocardial ischaemia reperfusion injury

Yu-Ming Ding, Elsa Ching Chan, Li-Chang Liu, Zhi-Wei Liu, Qiong Wang, Jian-Li Wang, Xiao-Pei Cui, Fan Jiang, Xiao-Sun Guo

Clinical and Experimental Pharmacology and Physiology | WILEY | Published : 2020

Abstract

Myocardial ischaemia reperfusion (I/R) injury is one of the leading causes of coronary artery disease-associated morbidity and mortality. While different strategies have been used to limit I/R injuries, cardiac functions often do not recover to the normal level as anticipated. Recent studies have pointed to important roles of long noncoding RNAs (lncRNAs) in the development of myocardial I/R injury. LncRNA is a class of RNA molecules of more than 200 nucleotides in length which are not translated into proteins. I/R causes dysregulation of lncRNA expression in cardiomyocytes, thereby affecting multiple cellular functions including mitochondrial homeostasis, apoptosis, necrosis and autophagy, ..

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Grants

Awarded by Shandong Province Science and Technology Program


Awarded by Natural Science Foundation of Shandong Province


Awarded by Shandong University Student Science and Technology Innovation Fund


Awarded by National Natural Science Foundation of China


Awarded by Shandong university cheeloo college of medicine undergraduate teaching reform and research


Funding Acknowledgements

Shandong Province Science and Technology Program, Grant/Award Number: 2017GSF218006, 2018GSF118016, 2018GSF118019 and 2019GSF108052; Natural Science Foundation of Shandong Province, Grant/Award Number: ZR2019HM016; Shandong University Student Science and Technology Innovation Fund, Grant/Award Number: 2019373; National Natural Science Foundation of China, Grant/Award Number: 81201391, 81401571 and 81770469; Shandong university cheeloo college of medicine undergraduate teaching reform and research, Grant/Award Number: qlyxjy-201839 and qlyxjy-201848