Journal article

Feasibility of Continuous Infusions of Acyclovir

Christine K O'Leary, Cheryl Jones, Penelope A Bryant, Yara-Natalie Abo, Joshua Osowicki, Amanda Gwee

The Pediatric Infectious Disease Journal | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

Current guidelines for severe herpes simplex virus infection recommend 21 days of intravenous therapy. The thrice-daily administration of intravenous acyclovir makes it challenging to deliver as outpatient therapy. We describe 2 cases with confirmed or presumed neonatal herpes simplex virus encephalitis treated with acyclovir administered as a continuous-infusion at home and review the pharmacologic and clinical evidence for continuous infusions of acyclovir.