Data on the modulatory effects of a single bolus dexamethasone on the surface marker expression of various leucocyte subsets
DF Draxler, CR Bain, R Taylor, S Wallace, O Gouldthorpe, TB Corcoran, PS Myles, K Bozaoglu, RL Medcalf
DATA IN BRIEF | ELSEVIER | Published : 2020
Dexamethasone is frequently administered to surgical patients for anti-emetic prophylaxis. We have examined the immunomodulatory effects of a single bolus of dexamethasone on circulating peripheral blood mononuclear cells (PBMCs) in the same 10 healthy male volunteers, previously used in our investigation on early in vivo effects of a single anti-emetic dose of dexamethasone on innate immune cell gene expression and activation . Blood samples were drawn at baseline, 2 h, 4 h and 24 h. Immune cell phenotypes were examined with flow cytometry. In this data article the expression strength of markers involved in immune activation and immunosuppression as well as maturation, migration, cell de..View full abstract
Awarded by Australian and New Zealand College of Anaesthetists (ANZCA) pilot grant funds
Awarded by Australian National Health and a Medical Research Council (NHMRC)
DD and CB contributed equally to the present manuscript (i.e. shared first authorship). KB and RM share senior authorship. Funding was kindly provided by the Australian and New Zealand College of Anaesthetists (ANZCA) pilot grant funds (Project No. p15008), Australian National Health and a Medical Research Council (NHMRC) Project Grant (APPI020284). KB is supported by an E.H Flack Fellowship. No competing interests declared.