Thoughtful Clinical Use of Pharmacogenetics in Child and Adolescent Psychopharmacology.
Laura B Ramsey, Lisa B Namerow, Jeffrey R Bishop, J Kevin Hicks, Chad Bousman, Paul E Croarkin, Carol A Mathews, Sara L Van Driest, Jeffrey R Strawn
Journal of the American Academy of Child & Adolescent Psychiatry | Elsevier BV | Published : 2021
AACAP's recent policy statement on Clinical Use of Pharmacogenetic Tests in Prescribing Psychotropic Medications for Children and Adolescents1 recommends that "clinicians avoid using pharmacogenetic testing to select psychotropic medications in children and adolescents." We agree that there are limitations to the nascent evidence base for using pharmacogenetics, especially in combinatorial form (eg, test results that bin medications based on multiple genes). However, all-or-nothing recommendations fail to recognize the nuance and context of this testing and contrast with the AACAP Facts for Families on pharmacogenetic testing. Moreover, pharmacogenetic testing may inform dosing for antidepre..View full abstract