Journal article

Synthesis of a tertiary amine by direct reductive amination of a carbonyl compound to form a scorpionate ligand; formation of Mn (II), Zn (II) and Cd (II) complexes, DFT calculations and, molecular docking studies

Mohammad Taher Rezaei, Hassan Keypour, Mehdi Bayat, Elham Soltani, Mahdi Jamshidi, Robert William Gable

JOURNAL OF MOLECULAR STRUCTURE | ELSEVIER | Published : 2021

Abstract

A hexadentate, asymmetric tripodal scorpionate type ligand, [[N1-Pyridin-2-ylmethyl-N1-[2-(4-pyridine-2-ylmethyl-piperazine-1-yl)-ethyl]-ethane-1,2-diamine]] (L) has been prepared. To form this ligand, the direct reductive amination of a carbonyl compound by NaBH4 was used for the synthesis of tertiary amine. The complexes [MnL])ClO4(2, [CdL])ClO4(2, [ZnL])ClO4(2 have also been prepared. The synthesized compounds were characterized by elemental analyses, FT-IR, ESI-MS and, NMR spectroscopy. An X-ray crystal structure of [MnL] (ClO4)2, shows that the coordination environment around the manganese is a distorted trigonal prism. The nature of metal–ligand bonding in the complexes was investigate..

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University of Melbourne Researchers