Journal article

Increasing Objective Cardiometabolic Burden Associated With Attenuations in the P3b Event-Related Potential Component in Older Adults

Hannah AD Keage, Daniel Feuerriegel, Danielle Greaves, Emma Tregoweth, Scott Coussens, Ashleigh E Smith

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2020

Abstract

Cardiometabolic diseases and risk factors increase the risk of late-life cognitive impairment and dementia and have also been associated with detrimental gray and white matter changes. However, the functional brain changes associated with cardiometabolic health in late-life are unclear. We sought to characterize these functional changes by recording event-related potentials (ERPs) during an n-back working memory task (0, 1, and 2 back) in 85 adults (60% female) between 50 and 80 years of age. Due to a stratified recruitment approach, participants varied widely in relation to cognitive function and cardiometabolic health. Standard and objective cut-offs for high blood glucose, waist to hip ra..

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Grants

Awarded by NHMRC Dementia Research Leadership Fellowship


Awarded by NHMRC-ARC Dementia Research Development Fellowship


Funding Acknowledgements

DG was supported by Australian Government Research Training Program Scholarship. HK was supported by a NHMRC Dementia Research Leadership Fellowship (GNT1135676). AS was supported by an NHMRC-ARC Dementia Research Development Fellowship (GNT1097397).