Ca2 Release via IP3 Receptors Shapes the Cardiac Ca2 Transient for Hypertrophic Signaling.
Hilary Hunt, Agnė Tilūnaitė, Greg Bass, Christian Soeller, H Llewelyn Roderick, Vijay Rajagopal, Edmund J Crampin
Biophysical Journal | Biophysical Society | Published : 2020
Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodine receptors for cellular contraction, whereas signaling downstream of G-protein-coupled receptors stimulates Ca2+ release via inositol 1,4,5-trisphosphate receptors (IP3Rs), engaging hypertrophic signaling pathways. Modulation of the amplitude, duration, and duty cycle of the cytosolic Ca2+ contraction signal and spatial localization have all been proposed to encode this hypertrophic signal. Given current knowledge of IP3Rs, we develop a model describing the effect of functional interaction (cross talk) ..View full abstract
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Awarded by Australian Research Council
This research was supported in part by the Australian Government through the Australian Research Council Discovery Projects funding scheme (project DP170101358). H.L.R. wishes to acknowledge financial support from the Research Foundation Flanders through project grant G08861N and Odysseus programme grant 90663.