Journal article

Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata

Justin Im, Md Taufiqul Islam, Deok Ryun Kim, Faisal Ahmmed, Yun Chon, K Zaman, Ashraful Islam Khan, Mohammad Ali, Dipika Sur, Suman Kanungo, Shanta Dutta, Sujit K Bhattacharya, Gordon Dougan, Kathryn E Holt, Florian Marks, Jerome H Kim, Firdausi Qadri, John D Clemens

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2020


We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95%..

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University of Melbourne Researchers


Awarded by Bill & Melinda Gates Foundation

Funding Acknowledgements

The research was supported by the Diseases of the Most Impoverished Program of the Bill & Melinda Gates Foundation. This publication was made possible through a grant from the Bill & Melinda Gates Foundation (OPP1171432) awarded to JC. GD was supported by Wellcome. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.