Book Chapter
Antibody Mediated Rejection: Are We There Yet?
GP Westall, LC Sullivan
Essentials in Lung Transplantation | Springer International Publishing | Published : 2018
Abstract
The diagnosis, management and treatment of antibody-mediated rejection (AMR) following lung transplantation remains challenging, but is associated with both acute and chronic lung allograft dysfunction (CLAD). Confidence for the diagnosis of AMR increases according to how many of the diagnostic tenets are present that include anti-HLA donor specific antibodies (DSA), C4d staining and histological changes centered around the capillary septum. Future studies on pulmonary AMR will be facilitated by the recent publication of a consensus statement on AMR in lung transplantation.